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Live Biotherapeutic Products and Microbiome Manufacturing Market by 2035

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Live Biotherapeutic Products and Microbiome Contract Manufacturing Market– Current Scenario and Future Trends

The human body is known to harbor numerous communities of microbes, including both beneficial and harmful species, which are collectively referred to as the microbiota. Likewise, the ecological system of commensal, symbiotic, and perhaps pathogenic microorganisms that reside within a host system is called the microbiome.

Given the role of the microbiota in both disease development and pathogenesis, the concept of microbiome-based therapeutics has generated significant enthusiasm within the medical science community, defining a new frontier in the field of medicine. In fact, the last two decades have witnessed several developments in the field of microbiome research and their therapeutic applications. Some of the various benefits offered by the human microbiota include:

However, there are known unmet needs related to manufacturing and research capabilities, quality of products, and time to market, that have restricted growth of this domain to a certain extent. As a result of this, outsourcing various aspects of product development is gradually emerging as a popular trend for stakeholders engaged in this field.

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Currently, many microbiome therapy developers prefer to engage the services of an experienced contract service provider, rather than investing in developing novel capabilities in-house.

The Evolving Landscape of Live Biotherapeutic Products and Microbiome Manufacturing Domain

During our research, we came across 27 industry players that claim to be engaged in the manufacturing of microbiome-based biologics for therapeutic purposes. Stakeholders claim to offer a range of services, across different scales of operations and over 60% of such products are packaged in sachets or pouches. The growing pipeline and the increasing demand for effective therapeutic interventions, has spurred the establishment of many companies in the last decades.

Companies have actively undertaken strategic initiatives, such as entering into mutually beneficial partnerships and expanding their capacities in order to keep pace with the growing demand

During our research, we identified various recent development initiatives (partnerships and collaborations, mergers and acquisitions and expansions) that have been undertaken in the microbiome manufacturing industry, during the period between 2016 and 2021.

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In recent years, there has been a steady increase in the number of recent development initiatives undertaken in this domain. This can be attributed to the fact that microbiome contract manufacturers are continuously investing in their facilities to cater to the growing demand for microbiome-based therapies.

Further, research agreements emerged as the most popular (36%) type of partnership model adopted by players engaged in this domain. The high research activity in this domain can be attributed to the efforts of players to further advance the development of their product offerings, across different phases.

Future Evolution of Live Biotherapeutic Products and Microbiome Manufacturing Market

During our research, we estimated the market under conservative, base and optimistic scenarios. As per the base case forecast scenario, the manufacturing market for live biotherapeutic products is estimated to grow at an annualized rate of ~20%, in the given time period. The opportunity is likely to be well distributed across various scales of operation, company sizes and key geographical regions

Key Questions Answered

  • Who are the key players engaged in offering contract manufacturing services for microbiome therapeutics?
  • What are the key challenges faced by microbiome contract manufacturers?
  • Who are the most likely partners (microbiome-based live biotherapeutic drug developers) for microbiome contract manufacturers?
  • What is the annual clinical demand for microbiome-based live biotherapeutics?
  • What is the current, installed contract manufacturing capacity for live biotherapeutics?
  • What are the key factors influencing the make (manufacture in-house) versus buy (outsource) decision in this field?
  • What are the various initiatives undertaken by big pharma players in this domain?
  • What percentage of live biotherapeutics manufacturing operations are outsourced to service providers?
  • How is the current and future market opportunity likely to be distributed across key market segments?
  • What are the anticipated future trends related to live biotherapeutics manufacturing?

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